KETAMINE HYPERTENSION FUNDAMENTALS EXPLAINED

Metabolism Ketamine is metabolized through N-dealkylation into the Energetic metabolite norketamine mostly by CYP2B6 and CYP3A4 and to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation on the cyclohexone ring to type hydroxynorketamine compounds via CYP-dependent pathways, which are conjugated with glucuronic acid and subseq